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Playstation 2 - ESPN Major League Baseball cheats

Easy Perfect Game:
Enter to the game setting and go to "AI batting". Modify everything to 100.

Better chance of hitting a homerun:
Hold Left Analog-stick Up. This works well when using a power hitter.

Running into the catcher:
When running home, hold Square and the baserunner will knock the catcher over, 
and possibly drop the ball.